It is becoming increasingly clear that diet produces rapid epigenetic changes which may affect gene expression and thus metabolism.
Genetics plays a huge role in how individuals respond to food and nutrition, so understanding its role can accelerate genomic and metabolomic biomarker discovery.
We provide targeted or discovery-based biomarker identification and characterization using state-of-the-art instrumentation, including next-generation sequencing and mass spectrometry (MS) platforms. By studying epigenetic and metabolomic changes, our researchers can identify biomarkers that indicate the intake of both macronutrients (carbs, fats & proteins) as well as micronutrients/vitamins, and assess how these may be influenced by the presence of common variants and mutations in expressed genes.
Knowing how these nutrients and the products that contain them affect gene expression and metabolism, as well as how epigenetics can influence nutrient uptake, can potentially reveal ways to manipulate nutrition toward a more healthful outcome.
Our multi-disciplinary teams can assist you in nutrient biomarker identification for the purpose of developing functional food products and supplements, methodologies for determining the impact of nutrients or bioactive compounds on health and disease states, and ways of tracking enhanced nutrient profiles in foods, including fruits and vegetables.